A biomaterial is defined as a material that interacts with biological systems in order to evaluate, treat, increase or replace tissues, organs or functions of the organism. The most important characteristics for selecting a biomaterial are biocompatibility, the absence of harmful or toxic effects for the organism and the biomechanical properties capable of responding to the dynamic and static stresses to which the organism will be subjected during its life.
Biomaterials can be of natural origin or synthesized in the laboratory. Biomaterials, such as bone substitutes, are used regularly in regenerative dentistry and also for bone regeneration in orthopedics.
The purpose of synthetic bone substitutes is to mimic the biological properties of natural bone. Therefore, the morphology and properties of natural bone must be used as a standard that must be met by the ideal bone substitute. These substitutes have several advantages against autografts or xenografts, namely, their unlimited availability and the fact that they eliminate the risk of disease transmission. For the graft or bone substitute to be successful, there are three basic criteria, namely, osteogenesis, osteoinduction and osteoconduction.
Bonelike by Biosckin® is a synthetic bone substitute, composed of a three-phase material: HA, α and β-Tricalcium Phosphates (α-TCP and β-TCP). The α- and β-TCP phases are homogeneously dispersed in the HA matrix, resulting in a material with improved mechanical properties and improved bioactivity. In addition, the inclusion of ions in the composition of Bonelike by Biosckin®, such as fluorine and sodium, among others, makes it possible to achieve a chemical composition closer to the mineral phase of the bone.
Bonelike by Biosckin® is a synthetic bone substitute, composed of a three-phase material: HA, α and β-Tricalcium Phosphates (α-TCP and β-TCP). The α- and β-TCP phases are homogeneously dispersed in the HA matrix, resulting in a material with improved mechanical properties and improved bioactivity. In addition, the inclusion of ions in the composition of Bonelike by Biosckin®, such as fluorine and sodium, among others, makes it possible to achieve a chemical composition closer to the mineral phase of the bone.
For the application Bonelike by Biosckin® in the surgical treatment of compartmental osteoarthritis of the knee, there was an extensive penetration of bone growth through the porous structure of the bone substitute in an implantation period as early as 6 months. The implanted Bonelike by Biosckin® allowed the penetration of osteoprogenitor cells, the migration and adhesion of cells, enabling the growth of new bone and thus forming a strong connection with the host bone, which provides stability and osteointegration.
